/* Biblioteca Diagnóstica Onkogenetik — F6
   Tokens alineados a science.css / design system. Sin submarca. */

.page-diagnostic,
.page-diagnostic-hub {
  --dl-ink: #0b1f3a;
  --dl-text: #13233a;
  --dl-slate: #5b6b7c;
  --dl-clinical: #2f6fed;
  --dl-mist: #eef3f8;
  --dl-surface: #fbfcfe;
  --dl-line: rgba(11, 31, 58, 0.1);
  --dl-serif: "Newsreader", Georgia, serif;
  --dl-sans: "Source Sans 3", system-ui, sans-serif;
  background:
    linear-gradient(180deg, #f7fafc 0%, #eef3f8 40%, #f4f7fb 100%);
  color: var(--dl-text);
  font-family: var(--dl-sans);
}

.visually-hidden {
  position: absolute !important;
  width: 1px; height: 1px;
  padding: 0; margin: -1px;
  overflow: hidden; clip: rect(0,0,0,0);
  white-space: nowrap; border: 0;
}

.dl-kicker {
  margin: 0 0 0.45rem;
  font-size: 0.72rem;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--dl-slate);
  font-weight: 600;
}

.onkoteca-mark {
  display: inline-block;
  line-height: 0;
  text-decoration: none;
  color: inherit;
}
.onkoteca-mark img {
  display: block;
  width: auto;
  max-width: min(11rem, 46vw);
  height: auto;
  object-fit: contain;
}
.onkoteca-mark--hub {
  margin: 0 0 0.85rem;
}
.onkoteca-mark--hub img {
  max-width: min(12rem, 52vw);
}
.onkoteca-mark--article {
  margin: 0 0 0.75rem;
}
.onkoteca-mark--article img {
  max-width: min(9.5rem, 44vw);
}

.dl-h2 {
  margin: 0 0 0.55rem;
  font-family: var(--dl-serif);
  font-weight: 560;
  font-size: clamp(1.45rem, 2.4vw, 1.85rem);
  color: var(--dl-ink);
  letter-spacing: -0.015em;
  line-height: 1.2;
}

.dl-lead {
  margin: 0 0 1.1rem;
  color: var(--dl-slate);
  max-width: 40rem;
  line-height: 1.5;
}

.dl-deck {
  margin: 0.75rem 0 0;
  max-width: 36rem;
  color: var(--dl-slate);
  font-size: 1.05rem;
  line-height: 1.55;
}

.dl-prose {
  margin: 0 0 0.85rem;
  line-height: 1.6;
  max-width: 46rem;
  font-size: 1.02rem;
}

.dl-why {
  margin: -0.35rem 0 1rem;
  font-size: 0.9rem;
  color: var(--dl-slate);
  font-style: italic;
}

.dl-abbr {
  display: inline-block;
  margin-left: 0.4rem;
  font-family: var(--dl-sans);
  font-size: 0.72em;
  font-weight: 600;
  letter-spacing: 0.04em;
  color: var(--dl-clinical);
  vertical-align: middle;
}

/* —— Hub —— */
.dl-hub-hero {
  padding: 2.1rem 0 1.5rem;
  background:
    radial-gradient(ellipse 50% 60% at 100% 0%, rgba(47, 111, 237, 0.07), transparent 55%),
    linear-gradient(165deg, #fbfcfe 0%, #eef3f8 55%, #e8eef5 100%);
  border-bottom: 1px solid var(--dl-line);
}
.dl-hub-hero h1 {
  margin: 0;
  font-family: var(--dl-serif);
  font-weight: 560;
  font-size: clamp(1.9rem, 4vw, 2.75rem);
  color: var(--dl-ink);
  letter-spacing: -0.02em;
  line-height: 1.1;
  max-width: 16ch;
}

.dl-search {
  margin-top: 1.25rem;
  display: flex;
  gap: 0.5rem;
  max-width: 36rem;
}
.dl-search input {
  flex: 1;
  min-width: 0;
  border: 1px solid rgba(11, 31, 58, 0.16);
  background: #fff;
  padding: 0.72rem 0.95rem;
  font: inherit;
  border-radius: 2px;
}
.dl-search input:focus {
  outline: 2px solid rgba(47, 111, 237, 0.35);
  outline-offset: 1px;
}
.dl-suggest {
  margin-top: 0.35rem;
  max-width: 36rem;
  background: #fff;
  border: 1px solid var(--dl-line);
}
.dl-suggest a {
  display: block;
  padding: 0.65rem 0.85rem;
  text-decoration: none;
  color: var(--dl-text);
  border-bottom: 1px solid rgba(11, 31, 58, 0.06);
  font-size: 0.95rem;
}
.dl-suggest a:hover { background: var(--dl-mist); }
.dl-hub-meta {
  margin: 0.85rem 0 0;
  font-size: 0.86rem;
  color: var(--dl-slate);
}

.dl-hub-body { padding: 1.75rem 0 3.5rem; }

.dl-toolbar { margin-bottom: 1.25rem; }
.dl-filters {
  display: flex;
  flex-wrap: wrap;
  gap: 0.4rem;
  margin: 0.5rem 0 0.85rem;
}
.dl-filter {
  appearance: none;
  border: 1px solid rgba(11, 31, 58, 0.14);
  background: #fff;
  color: var(--dl-ink);
  padding: 0.4rem 0.75rem;
  font: inherit;
  font-size: 0.88rem;
  cursor: pointer;
  border-radius: 2px;
}
.dl-filter.is-active,
.dl-filter:hover {
  border-color: var(--dl-clinical);
  color: var(--dl-clinical);
}
.dl-filter:focus-visible {
  outline: 2px solid rgba(47, 111, 237, 0.4);
  outline-offset: 2px;
}

.dl-legend {
  display: flex;
  flex-wrap: wrap;
  gap: 0.65rem 1.1rem;
  font-size: 0.82rem;
  color: var(--dl-slate);
  margin: 0 0 1rem;
}
.dl-legend--compact { margin-top: 0.25rem; }

.dl-row {
  display: grid;
  grid-template-columns: 1fr auto;
  gap: 1rem;
  align-items: start;
  padding: 1.05rem 0;
  border-bottom: 1px solid var(--dl-line);
}
.dl-row.is-hidden { display: none; }
.dl-row__title {
  margin: 0 0 0.35rem;
  font-family: var(--dl-serif);
  font-size: 1.2rem;
  font-weight: 560;
  color: var(--dl-ink);
  line-height: 1.25;
}
.dl-row__title a {
  color: inherit;
  text-decoration: none;
}
.dl-row__title a:hover { color: var(--dl-clinical); }
.dl-row__def {
  margin: 0 0 0.55rem;
  color: var(--dl-slate);
  font-size: 0.95rem;
  line-height: 1.45;
  max-width: 48rem;
}
.dl-row__studies {
  display: flex;
  flex-wrap: wrap;
  gap: 0.35rem 0.75rem;
  font-size: 0.84rem;
  color: var(--dl-text);
}
.dl-mini { white-space: nowrap; }
.dl-row__go {
  font-size: 0.92rem;
  color: var(--dl-clinical);
  text-decoration: none;
  font-weight: 600;
  white-space: nowrap;
  margin-top: 0.25rem;
}
.dl-row__go:hover { text-decoration: underline; }

.dl-areas-note {
  margin-top: 2.5rem;
  padding-top: 1.25rem;
  border-top: 1px solid var(--dl-line);
  color: var(--dl-slate);
  font-size: 0.92rem;
}
.dl-empty-state {
  padding: 1.5rem 0;
  color: var(--dl-slate);
}

/* —— Disease page —— */
.dl-entity-hero {
  padding: 1.6rem 0 1.2rem;
  background:
    linear-gradient(165deg, #fbfcfe 0%, #eef3f8 70%);
  border-bottom: 1px solid var(--dl-line);
}
.dl-crumb {
  margin: 0 0 0.75rem;
  font-size: 0.84rem;
  color: var(--dl-slate);
}
.dl-crumb a { color: inherit; text-decoration: none; }
.dl-crumb a:hover { color: var(--dl-ink); }
.dl-entity-title {
  margin: 0;
  font-family: var(--dl-serif);
  font-weight: 560;
  font-size: clamp(1.75rem, 3.5vw, 2.55rem);
  color: var(--dl-ink);
  letter-spacing: -0.02em;
  line-height: 1.12;
  max-width: 22ch;
}
.dl-entity-def {
  margin: 0.7rem 0 0;
  max-width: 42rem;
  color: var(--dl-slate);
  font-size: 1.05rem;
  line-height: 1.55;
}
.dl-actions {
  display: flex;
  gap: 0.75rem;
  margin-top: 1rem;
}
.dl-action {
  appearance: none;
  background: transparent;
  border: 0;
  border-bottom: 1px solid rgba(11, 31, 58, 0.25);
  color: var(--dl-ink);
  font: inherit;
  font-size: 0.88rem;
  padding: 0.15rem 0;
  cursor: pointer;
  text-decoration: none;
}
.dl-action:hover { border-color: var(--dl-clinical); color: var(--dl-clinical); }

.dl-limited {
  margin-top: 1.1rem;
  padding: 0.85rem 0 0.15rem;
  border-top: 1px solid var(--dl-line);
  max-width: 40rem;
}
.dl-limited p:last-child { margin: 0; color: var(--dl-slate); font-size: 0.95rem; }

.dl-sticky {
  position: sticky;
  top: 0;
  z-index: 20;
  display: flex;
  gap: 0.15rem;
  overflow-x: auto;
  -webkit-overflow-scrolling: touch;
  background: rgba(251, 252, 254, 0.94);
  backdrop-filter: blur(8px);
  border-bottom: 1px solid var(--dl-line);
  padding: 0.45rem 1.25rem;
  scrollbar-width: thin;
}
.dl-sticky a {
  flex: 0 0 auto;
  padding: 0.45rem 0.7rem;
  font-size: 0.84rem;
  color: var(--dl-slate);
  text-decoration: none;
  border-bottom: 2px solid transparent;
  white-space: nowrap;
}
.dl-sticky a:hover,
.dl-sticky a.is-active {
  color: var(--dl-ink);
  border-bottom-color: var(--dl-clinical);
}

.dl-layout {
  padding: 1.5rem 0 3.5rem;
  display: flex;
  flex-direction: column;
  gap: 2rem;
}

/* Quick consult */
.dl-quick {
  background: #fff;
  border: 1px solid var(--dl-line);
  border-left: 3px solid var(--dl-clinical);
  padding: 1.25rem 1.35rem 1.4rem;
}
.dl-quick__grid {
  display: grid;
  gap: 1rem 1.35rem;
  grid-template-columns: 1fr;
}
@media (min-width: 768px) {
  .dl-quick__grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }
}
@media (min-width: 1100px) {
  .dl-quick__grid {
    grid-template-columns: repeat(4, minmax(0, 1fr));
  }
  .dl-quick__cell--wide { grid-column: 1 / -1; }
}
.dl-quick__specimen {
  margin: 0;
  font-size: 1.15rem;
  font-weight: 600;
  color: var(--dl-ink);
  font-family: var(--dl-serif);
}
.dl-chip-list {
  list-style: none;
  margin: 0;
  padding: 0;
  display: flex;
  flex-direction: column;
  gap: 0.35rem;
}
.dl-chip {
  display: flex;
  align-items: baseline;
  gap: 0.4rem;
  font-size: 0.92rem;
}
.dl-chip__mark {
  color: var(--dl-ink);
  font-weight: 700;
  width: 1rem;
  flex: 0 0 auto;
}
.dl-chip--essential .dl-chip__mark { color: var(--dl-clinical); }
.dl-chip--conditional .dl-chip__mark { color: #8a6a3d; }
.dl-empty { margin: 0; color: var(--dl-slate); }

.dl-bullets {
  margin: 0;
  padding-left: 1.1rem;
  color: var(--dl-text);
}
.dl-bullets li { margin-bottom: 0.3rem; line-height: 1.45; }

.dl-keypoints__list {
  margin: 0;
  padding-left: 1.2rem;
  max-width: 44rem;
}
.dl-keypoints__list li {
  margin-bottom: 0.55rem;
  line-height: 1.5;
}

/* Recommendations */
.dl-recs { display: flex; flex-direction: column; gap: 0.45rem; }
.dl-rec {
  border: 1px solid var(--dl-line);
  background: #fff;
  border-radius: 2px;
}
.dl-rec summary {
  display: grid;
  grid-template-columns: 1.25rem 1fr;
  gap: 0.35rem 0.65rem;
  padding: 0.85rem 1rem;
  cursor: pointer;
  list-style: none;
  align-items: start;
}
.dl-rec summary::-webkit-details-marker { display: none; }
.dl-rec__mark {
  font-weight: 700;
  color: var(--dl-ink);
  line-height: 1.4;
}
.dl-rec__main {
  display: flex;
  flex-wrap: wrap;
  align-items: baseline;
  gap: 0.35rem 0.75rem;
}
.dl-rec__name {
  font-weight: 700;
  color: var(--dl-ink);
  font-size: 1.02rem;
}
.dl-rec__level {
  font-size: 0.78rem;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--dl-slate);
  font-weight: 600;
}
.dl-rec__sum {
  grid-column: 2;
  color: var(--dl-slate);
  font-size: 0.92rem;
  line-height: 1.4;
}
.dl-rec__spec {
  grid-column: 2;
  font-size: 0.84rem;
  color: var(--dl-ink);
  font-weight: 600;
}
.dl-rec__body {
  padding: 0 1rem 1rem 2.9rem;
  border-top: 1px solid rgba(11, 31, 58, 0.06);
}
.dl-rec__body p {
  margin: 0.65rem 0 0;
  font-size: 0.95rem;
  line-height: 1.5;
}
.dl-rec__why { color: var(--dl-slate); font-size: 0.88rem !important; }
.dl-rec[open] summary { background: rgba(238, 243, 248, 0.55); }

@media (min-width: 900px) {
  .dl-rec summary {
    grid-template-columns: 1.25rem minmax(10rem, 0.9fr) minmax(12rem, 1.4fr) minmax(7rem, 0.7fr);
    align-items: center;
  }
  .dl-rec__sum, .dl-rec__spec { grid-column: auto; }
  .dl-rec__main { flex-direction: column; gap: 0.15rem; align-items: flex-start; }
}

/* Figures */
.dl-figure {
  margin: 1.25rem 0 0;
  padding: 1rem 0 0;
  border-top: 1px solid var(--dl-line);
}
.dl-figure--primary {
  border-top: 0;
  padding-top: 0.25rem;
  margin-top: 0.5rem;
}
.dl-figure__title {
  margin: 0;
  font-family: var(--dl-serif);
  font-size: 1.15rem;
  color: var(--dl-ink);
  font-weight: 560;
}
.dl-figure__q {
  margin: 0.35rem 0 0;
  color: var(--dl-slate);
  font-size: 0.95rem;
}
.dl-figure__frame {
  position: relative;
  margin-top: 0.85rem;
  background: #fff;
  border: 1px solid var(--dl-line);
  padding: 0.75rem;
  overflow: auto;
}
.dl-figure__frame img {
  display: block;
  width: 100%;
  height: auto;
  max-width: 100%;
}
.dl-figure__expand {
  position: absolute;
  top: 0.55rem;
  right: 0.55rem;
  appearance: none;
  border: 1px solid rgba(11, 31, 58, 0.16);
  background: rgba(255, 255, 255, 0.92);
  font: inherit;
  font-size: 0.78rem;
  padding: 0.3rem 0.55rem;
  cursor: pointer;
  color: var(--dl-ink);
}
.dl-figure.is-expanded .dl-figure__frame {
  position: fixed;
  inset: 3vh 3vw;
  z-index: 80;
  padding: 1.25rem;
  overflow: auto;
  box-shadow: 0 12px 40px rgba(7, 22, 40, 0.18);
}
.dl-figure.is-expanded .dl-figure__frame img { max-width: none; width: auto; min-width: 100%; }
.dl-figure__caption {
  margin: 0.55rem 0 0;
  font-size: 0.88rem;
  color: var(--dl-slate);
}

/* WHO / ICC */
.dl-who-icc {
  display: grid;
  gap: 1rem;
  margin: 1rem 0;
}
@media (min-width: 800px) {
  .dl-who-icc { grid-template-columns: 1fr 1fr; }
}
.dl-who-icc__col {
  padding: 0.85rem 1rem;
  background: #fff;
  border: 1px solid var(--dl-line);
  border-top: 2px solid var(--dl-ink);
}
.dl-who-icc__col h3,
.dl-who-icc__col h4 {
  margin: 0 0 0.5rem;
  font-size: 0.78rem;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--dl-slate);
}
.dl-diff-note {
  margin: 0.75rem 0 1rem;
  padding: 0.75rem 0 0;
  border-top: 1px dashed var(--dl-line);
}
.dl-diff-note h3,
.dl-diff-note h4 {
  margin: 0 0 0.4rem;
  font-size: 0.95rem;
  color: var(--dl-ink);
}

.dl-specimen {
  display: grid;
  gap: 1rem;
  background: #fff;
  border: 1px solid var(--dl-line);
  padding: 1rem 1.15rem;
  max-width: 36rem;
}
.dl-specimen__val {
  margin: 0;
  font-family: var(--dl-serif);
  font-size: 1.25rem;
  color: var(--dl-ink);
  font-weight: 560;
}

.dl-refs {
  margin: 0;
  padding-left: 1.2rem;
  max-width: 46rem;
}
.dl-refs li { margin-bottom: 0.55rem; line-height: 1.4; }
.dl-ref__title { display: block; color: var(--dl-ink); }
.dl-ref__meta { display: block; font-size: 0.86rem; color: var(--dl-slate); }
.dl-refs-more { margin-top: 0.75rem; }
.dl-refs-more summary {
  cursor: pointer;
  color: var(--dl-clinical);
  font-weight: 600;
}

.dl-atlas-section { padding-top: 0.25rem; }

@media (max-width: 767px) {
  .dl-row {
    grid-template-columns: 1fr;
    gap: 0.5rem;
  }
  .dl-entity-title { max-width: none; }
  .dl-hub-hero { padding: 1.5rem 0 1.15rem; }
  .dl-quick { padding: 1rem; }
  .dl-rec summary { padding: 0.75rem 0.85rem; }
  .dl-rec__body { padding-left: 1rem; }
  .dl-sticky { padding-left: 0.75rem; padding-right: 0.75rem; }
}

@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  .dl-figure__frame,
  .dl-rec,
  .dl-filter {
    transition: none !important;
  }
}

@media (min-width: 768px) {
  .dl-figure__frame,
  .dl-rec,
  .dl-filter {
    transition: border-color 160ms ease, background-color 160ms ease;
  }
}